Alternate positions of conserved water molecules.

(A) Among five conserved water molecules in the apo-form binding pocket, three are observed to have alternate positions. (B) Three out of four conserved water molecules demonstrate alternate positions in the BD2-L10 complex. The ligand and selected residues are shown as sticks. Water molecules are shown as spheres. |2Fo|-|Fc| map of water molecules contoured at 1.0σ. The hydrogen bonds are shown as broken lines.