Additional results for evaluating the power of PRSet using a pathway enrichment approach.

a) Simulation analyses– 4050 pathways. Performance was defined as the Kendall correlation between the competitive P-value for each software and the empirical pathway ranking. Boxplots illustrate the values of Kendall rank correlation coefficients (τ) for PRSet, MAGMA and LDSC for each combination of heritability (h² = 0.1, 0.5) base sample size used in GWAS n = (50K, 125K, 250K), and target sample size n = (1K, 10K, 100K). b) Kendall correlation coefficients (τ) between pathway enrichment analyses and MalaCards relevance scores. Bar plots illustrate joint results of the six databases used to define pathways. *empirical P-value < 0.05.

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