Aβ deposition in the cerbral cortex of stranded dolphins.

(A) Anti-Aβ IHC demonstrates Aβ⁺ plaques in the cerebral cortex of stranded dolphins. (B) Intraneuronal Aβ⁺ accumulation was aslo observed throughout upper and lower cortical layers. (C) High-resolution digital patholgy scans of pyramidal neurons in the ACtx containing dense intracellalur Aβ⁺ inclusions. (D) Large and sparse Aβ⁺ plaques were observed in the Md of stranded dolphins. (E-P) Aβ⁺ plaques were different in morphology as observed by H&E staining (E-H), MB silver staining (I-L) and Aβ⁺ IHC (M-P). Aβ⁺ plaques ranged from small focal with compact cores (E, I, M), primative immature cotton wool-like (F, J, N), to large and diffuse (G, K, O) and ill-defined (H, L, P). Representative scale bar: 500 μm (A, B & D), 100 μm (C), 50 μm (E-P).