Aβ deposition in the cerbral cortex of stranded dolphins.
(A) Anti-Aβ IHC demonstrates Aβ+ plaques in the cerebral cortex of stranded dolphins. (B) Intraneuronal Aβ+ accumulation was aslo observed throughout upper and lower cortical layers. (C) High-resolution digital patholgy scans of pyramidal neurons in the ACtx containing dense intracellalur Aβ+ inclusions. (D) Large and sparse Aβ+ plaques were observed in the Md of stranded dolphins. (E-P) Aβ+ plaques were different in morphology as observed by H&E staining (E-H), MB silver staining (I-L) and Aβ+ IHC (M-P). Aβ+ plaques ranged from small focal with compact cores (E, I, M), primative immature cotton wool-like (F, J, N), to large and diffuse (G, K, O) and ill-defined (H, L, P). Representative scale bar: 500 μm (A, B & D), 100 μm (C), 50 μm (E-P).