The DAVID Functional Annotation Clustering tool was used to group genes demonstrating co-ordinate expression on the basis of sharing similar biological meaning.

The discovered gene groups were ranked according to the EASE enrichment score, which is the minus log transformation of the geometric mean of P-values from the enriched annotation terms associated with the different gene group members. Only groups with EASE scores larger than or equal to 4.0 were considered (geometric mean of Benjamini corrected P-values ≤0.05). For each group the relevant GO-terms for Biological Process are given, together with a list of the genes sharing that term, the number of genes in the query list mapped to any gene set in this ontology (List Total), the number of genes annotated to this gene set on the background list (Pop Hits), the mean Fold enrichment of the genes in the group, the Benjamini-corrected P value (the Fisher Exact Probability Value (representing the “degree of enrichment” of the annotation term within the group) further corrected for false discovery rate using the Benjamini correction) and the false discovery rate (FDR). In this table the two clusters within BioLayout cluster 001 were significantly enriched for terms relating to the formation of blood vessels, and immune cell selection, differentiation and activation.