Structure activity relationship of a few CNB-001 derivatives.
dataset
posted on 2013-02-20, 10:51 authored by Qi Chen, Marguerite Prior, Richard Dargusch, Amanda Roberts, Roland Riek, Cédric Eichmann, Chandramouli Chiruta, Tatsuhiro Akaishi, Kazuho Abe, Pamela Maher, David SchubertThe structure of CNB-001 is shown in Figure 1A. A series of CNB-001 derivatives were synthesized with the goal of removing the hydroxyl group and maintaining and/or improving biological activity in the glutamate based oxytosis assay and extracellular amyloid toxicity. Et (ethyl), Me (Methyl).
