Linear regression analysis of the predictors associated with the change score of pruritus intensity with dichotomized baseline Kt/V at its appropriate threshold value of 1.5.

NOTE. Each participant’s change score of pruritus intensity = follow-up VAS score of pruritus intensity – baseline VAS score of pruritus intensity. Similarly, each participant’s change score of a covariate = follow-up data of a covariate – baseline data of a covariate. The appropriate threshold of Kt/V, determined by generalized additive models and receiver operating characteristic analysis, was 1.5. Accordingly, the participants were classified into two categories: those with Kt/V <1.5 and those with Kt/V ≥1.5.

Abbreviations: AST = Aspartate transaminase; VAS = Visual analog scale.


Ca×P = Product of albumin-adjusted serum calcium (Ca) and serum phosphorus (P).


Model adjusted for covariates of baseline data only (gender, Kt/V, use of high-flux dialyzer, pruritus intensity, creatinine, uric acid, fasting glucose, phosphorus), R2 = 0.725.


Model adjusted for the important covariates at baseline (Kt/V, pruritus intensity, AST, and Ca×P) and the change scores of the covariates (uric acid, fasting glucose, and AST), R2 = 0.754.