Field potential duration prolongation with increased hERG channel blocker E-4031 drug concentrations.

Abbreviations: FPD- field potential duration, BR-beating rate.

Mean and S.D. of field potential durations from manually analysed field potential complexes (n = 25) were compared to those of corresponding averaged signals from CardioMDA in a drug dataset depicting the effect of E-4031 on human iPSC-derived CMs. The field potential duration rises as a result of increasing drug concentration. From the results obtained using our software, it can be seen that the changes in field potential duration correspond well to values obtained from manual analysis.