Distribution of identified differences between TPA and TPE proteins encoded by different functional gene groups.

Genetic differences were characterized in 983 similarly annotated genes and pseudogenes in both T. p. ssp. pertenue (TPE; Samoa D, CDC-2, and Gauthier) and T. p. ssp. pallidum strains (TPA; Nichols, DAL-1, SS14, Chicago). Only changes present in all investigated TPE strains when compared to all investigated TPA strains are shown in this table.

statistically significant results when compared to the genes encoding components of general metabolism. The p-value was corrected using Bonferroni correction for multiple comparisons to p = 0.008 and p-values lower than 0.008 were considered as statistically significant. p-values lower than 0.05 are also shown.

MSC (major sequence changes) were defined as 15 or more dispersed amino acid substitutions, indels longer than 10 amino acids, truncated and full length proteins (results of frameshift and reverted frameshift mutations, nonsense and start codon changing mutations).

not statistically significant.