Components of the post-translational machinery present in PML NBs.

Enzymes involved in post-translational modifications of proteins and described as associated with PML Nuclear Bodies, according to Van Damme et al.[34]. These proteins represent about 30% of all proteins associated with PML NBs, highlighting a potential integrative role of PML NBs in post-translational maturation of nuclear proteins. Proteins followed by a + sign are mainly involved in the transfer of post-translational moieties to protein substrates (e.g. kinases), whereas those with a − sign are associated to protein demodification (e.g. phosphatases). Uniprot accession IDs are in italic.