pgen.1009736.s010.xlsx (1.97 MB)
S1 Source Data -
dataset
posted on 2021-09-07, 17:41 authored by Wenfan Ke, Jordan N. Reed, Chenyu Yang, Noel Higgason, Leila Rayyan, Carolina Wählby, Anne E. Carpenter, Mete Civelek, Eyleen J. O’RourkeThis source data file includes all raw data and analysis presented in Figs 1E, 2B, 2C, 2F, 3A, 3B, 3C, 4B, 4C, 4E, 4F, 4G, 4H, 4J, 4K, 4L, 5B, 5C, 5D, 5E, 6B, 6C, 6D, 7D, 7E, S1E, S3A, S3B, S4A, S4B, S4C, S4D and S4E.
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identifying pharmacological targetsfar merely correlatedectopic fat depotsdiv >< passociated metabolic syndromemodel systems compatiblereport 14 genescandidate genes reportedobesity across phylogenywide association studiescausal obesity genesthroughput genetic screening3 dio geneshuman obesity loci3 geneshuman obesityrnai screeninginvertebrate modelprevent diodio ).several genesortholog genesgenes would293 genespromote obesityinduced obesityvivo study demonstratesrnai screenedphenotypic outcomeoverconsuming fructosenext challengeleading causeincreased interestidentified hundredshumans matchesheavy burdenhealthcare systemexperimentally defineelegans disease ’defining causalitycausally linkedcausality 293c also improves
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