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Results of LD Score regression analyses between psycho-cardiometabolic multimorbidity and various risk factors.
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posted on 2023-06-30, 17:33 authored by Vilte Baltramonaityte, Jean-Baptiste Pingault, Charlotte A. M. Cecil, Priyanka Choudhary, Marjo-Riitta Järvelin, Brenda W. J. H. Penninx, Janine Felix, Sylvain Sebert, Yuri Milaneschi, Esther WaltonResults of LD Score regression analyses between psycho-cardiometabolic multimorbidity and various risk factors.
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wide association studywide association studiesshared genetic influencespresent study aimedper standard deviationepidemiological studies indicatecoronary artery diseasebody fat percentage74 – 245 %), followedmoderately genetically correlatedidentify genetic variants>< sub ><uk biobank (<latent multimorbidity factor18 putative multimorbiditydiv >< pweakly correlatedpleiotropic variantsmultimorbidity (<>univariate genometrait liabilitytotal cholesterolsubstantial degreeresearch exploringobserved enrichmentmultivariate genomemortality worldwideleading causesldl cholesterollargest proportioninflammatory pathwaysgenes commonfindings advancefasting insulinchronic morbiditychildhood maltreatmentcardiometabolic diseases6 ).5 %).35 %)
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