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Download fileKinase genes with correlated decreased expression in metastatic samples.
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posted on 13.05.2022, 17:43 by David O. Holland, Valer Gotea, Kevin Fedkenheuer, Sushil K. Jaiswal, Catherine Baugher, Hua Tan, Michael Fedkenheuer, Laura ElnitskiKinase genes with correlated decreased expression in metastatic samples.
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therapeutic target identificationreceiving increased attentionplay causal rolesfind strong evidenceanatomic tumor locationssplicing events favoredidentify five examples103 primary tumorreceptor tyrosine kinasesdiv >< pcancer genome atlas367 metastatic samplesaberrant alternative splicingkinase isoform expressiondemonstrate differential apoptosismetastatic samplesdifferential expressionaberrant expressionsplicing regulatorsprimary tumorskinase ’isoform ratiosidentify subgroupsmetastatic melanomagene expressioncmgc kinases468 kinases123 kinasestcga ).slk </significant differenceresults revealrelated processesras </protein localizationnrtks ).new approachlittle correlationgenomic subtypesgene levelfunctional domainsdriver genesdownstream impactcould leadcell migrationbraf </alternative isoforms>( n23 %).13 %)
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