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IV-KAPhE assignments of S6K-α isoforms for any site annotated in PhosphoSitePlus as being phosphorylated by at least one of these isoforms in vivo or in vitro.

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posted on 13.05.2022, 17:43 by Brandon M. Invergo

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Accurate, high-coverage assignment of in vivo protein kinases to phosphosites from in vitro phosphoproteomic specificity data
PLOS Computational BiologyPLOS Computational Biology

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div >< pphosphorylation evidence ”).intracellular signaling processesdensely connected kinasephosphoproteomic specificity data>- kinase assignmentsignaling redundancyphosphorylation siteslabel kinasevivo </vitro </substrate networksubstrate assaystatistical modelsmall subsetsites targetedsimilar scopesignificant crossrobust basisprotein kinasespointing eithermultiple kinaseslimited knowledgekaphe outperformskaphe (“<human datacoverage assignmentbiochemical constraints

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