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Download fileExample genes with significant changes in isoform ratios after 3’ bias and sample impurity filtering.
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posted on 13.05.2022, 17:43 by David O. Holland, Valer Gotea, Kevin Fedkenheuer, Sushil K. Jaiswal, Catherine Baugher, Hua Tan, Michael Fedkenheuer, Laura ElnitskiExample genes with significant changes in isoform ratios after 3’ bias and sample impurity filtering.
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therapeutic target identificationreceiving increased attentionplay causal rolesfind strong evidenceanatomic tumor locationssplicing events favoredidentify five examples103 primary tumorreceptor tyrosine kinasesdiv >< pcancer genome atlas367 metastatic samplesaberrant alternative splicingkinase isoform expressiondemonstrate differential apoptosismetastatic samplesdifferential expressionaberrant expressionsplicing regulatorsprimary tumorskinase ’isoform ratiosidentify subgroupsmetastatic melanomagene expressioncmgc kinases468 kinases123 kinasestcga ).slk </significant differenceresults revealrelated processesras </protein localizationnrtks ).new approachlittle correlationgenomic subtypesgene levelfunctional domainsdriver genesdownstream impactcould leadcell migrationbraf </alternative isoforms>( n23 %).13 %)
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