Bootstrap-corrected model discrimination performance in terms of C-index, and associated 95% bootstrap confidence intervals (CI).
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posted on 2024-10-02, 05:54 authored by Autumn O’Donnell, Michael Cronin, Shirin Moghaddam, Eric WolsztynskiThe best-performing pipeline for each modelling strategy is highlighted in bold.
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systematic prostatectomy regimeprecision medicine approachpotential key predictorsncbi geo databaseevent machine learningappropriate therapeutic pathwaysoperative precision nomogramsroutine clinical informationregularised cox modelscommon clinical endpointsspecific survival horizonpatients even prioraccession gse21032 ).operative transcriptomics modelsmrna information comprisingmrna variables identifiedfree survival predictionoperative bcr predictionoperative predictionfree survivalmrna variablesclinical followclassification modelsbcr predictionbcr ).135 patientsyear survivalwould likelytreatment decisionretrospectively analysedresults showedprostate cancerpredictive accuracypatient profilesmodel discriminationmetrics consideredincluding confirmationexternal validationcould pavebiochemical recurrence000 features
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