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Expression of the S1731C Allele in Polyclonal Stable Cell Lines

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posted on 2013-01-20, 10:51 authored by Liam R Brunham, Roshni R Singaraja, Terry D Pape, Anish Kejariwal, Paul D Thomas, Michael R Hayden

ABCA1 protein (A) and mRNA (B) expression levels were determined in an untransfected control cell line, and cells transfected with wild-type ABCA1 or the S1731C variant. The cell line transfected with the S1731C allele expressed low levels of protein (A), but normal levels of mRNA (B), indicating that this variant impairs ABCA1 function by inhibiting the generation of a stable protein.

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