pone.0170483.g003.tif (290.48 kB)
S. mutans ADP-Glc PPase inhibition when Pi (empty circles) or MFP (filled circles) are present in the reaction mixture.
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posted on 2017-01-26, 00:45 authored by Ana M. Demonte, Matias D. Asencion Diez, Conrad Naleway, Alberto A. Iglesias, Miguel A. BallicoraCurves were obtained from reactions conducted at 1 mM Glc-1P, 2 mM ATP and 10 mM Mg2+.
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IPS synthesisIPS biosynthesisSodium monofluorophosphateMonofluorophosphate Blocks Internal Polysaccharide Synthesismutans ADP-glucose pyrophosphorylaseanticariogenic compoundStreptococcus mutans Streptococcus mutansmutans virulenceglycogen synthesismutans cellsEC1.5 mMEnzyme inhibitionIPS accumulationADP-glucose pyrophosphorylase2 mM sodium MFPsodium fluorideanticariogenic effect
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