OSM, OSMR and LIFR mRNA expression is present in human atherosclerotic plaques.

mRNA expression was measured in normal arteries and in carotid plaques by microarray analysis (A-C) and ISH was used to visualize OSM, OSMR and LIFR mRNA expression (red spots and shown by the black arrows) in two different stages of atherosclerosis development, the late fibroatheroma (D-I) and intimal xanthoma (J-O). A two-sided Student’s t-test assuming non-equal deviation was used to test for significance between normal and atherosclerotic arteries. ***p<0.001, ****p<0.0001.