pgen.1008420.g004.tif (93.34 kB)
Epas1 is an outlier in a demographically-controlled selection scan.
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posted on 2019-11-07, 18:29 authored by Rena M. Schweizer, Jonathan P. Velotta, Catherine M. Ivy, Matthew R. Jones, Sarah M. Muir, Gideon S. Bradburd, Jay F. Storz, Graham R. Scott, Zachary A. ChevironExome-wide distribution of population branch statistic (PBS) for Mt. Evans mice based on 5,182,530 SNPs from the exome. Horizontal line (red) indicates the top 0.1% percentile PBS of 500,000 neutral SNPs simulated under a realistic demographic scenario, and SNPs in hypoxia-related genes are highlighted in orange. The top ten hypoxia-related genes are labeled, with Epas1 indicated in bold text. SNPs with a PBS value below the top 0.1% percentile have been randomly down-sampled (1:20) for ease of plotting.
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100 micePeromyscus maniculatusdeer miceSNPdemographically-informed selection scanpleiotropic transcription factorsHIF targetslowland populationsdeer mice Evolutionary adaptationtranscription factorsgene Epas 1allele frequency differenceshypoxia-inducible factorstranscriptomic responsesEpas 1genomic evidenceTranscription factorsNorth American deer micegene regulationEpas 1 genotypemulti-trait adaptationEpas 1 genotype influences heart rateEpas 1 variantstranscription factor Epas 1pleiotropic effects
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