Epas1 is an outlier in a demographically-controlled selection scan.

Exome-wide distribution of population branch statistic (PBS) for Mt. Evans mice based on 5,182,530 SNPs from the exome. Horizontal line (red) indicates the top 0.1% percentile PBS of 500,000 neutral SNPs simulated under a realistic demographic scenario, and SNPs in hypoxia-related genes are highlighted in orange. The top ten hypoxia-related genes are labeled, with Epas1 indicated in bold text. SNPs with a PBS value below the top 0.1% percentile have been randomly down-sampled (1:20) for ease of plotting.