iNKT cells accumulate in the CNS during TMEV infection.
(A) Representative CD1d:α-GalCer tetramer staining on purified mononuclear cells from the CNS of wild type C57Bl/6 (left) and TCR Vα14 Tg mice (right) 8 days after infection with 104 pfu of TMEV. (B–C) Absolute number of CD1d:α-GalCer αβ T cells (left) and their fold increase (right) in the CNS after TMEV infection of C57Bl/6 mice (B) and Vα14 Tg mice (C). Absolute number of purified mononuclear cells from the CNS of C57Bl/6 (D) and Vα14 Tg mice (E). Data represent the mean ± SEM of 2 independent experiments with 2–4 pooled mice/observation.