estimates of lifetime cost per incident patient by diagnosis.

Ŧ. Costs have been adjusted for inflation at 2011 values using compound annual Italian National Consumer Price Indexes (ISTAT reference) from 2005 (112.92%) or 2006 (110.6%).

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. Surgical procedures and medical treatments were modelled on the basis of the Italian AIOM guidelines [16].

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. Surgical procedures and medical treatments were modelled on the basis of the Italian SIGO guidelines [17].

†††

. Surgical procedures and medical treatments were modelled on the basis of the Italian AIRC guidelines [18.].

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Respiratory recurrent papillomatosis (RRP).

††††

. Due to the lack of Italian data on RRP, surgical procedures and medical treatments were informed on the basis of U.S. data [20], [21].