Figure_5.tif (535.69 kB)
dhfr triple mutant He changes over time (50R/51I/108N).
figure
posted on 2013-03-16, 09:59 authored by Sean M. Griffing, Giselle M. Rachid Viana, Tonya Mixson-Hayden, Sankar Sridaran, Mohammad Tauqeer Alam, Alexandre Macedo de Oliveira, John W. Barnwell, Ananias A. Escalante, Marinete Marins Povoa, Venkatachalam UdhayakumarThe figure shows variation in He surrounding dhfr for parasites carrying a 50R/51I/108N mutants during the 1980s (n = 14) and 1990s (n = 92). Note that He around the triple mutants seems similar between the two decades. The two flat, dashed lines represent two different estimates of neutral He in Brazil.