ceRNA Hypothesis.

A) Schematic of mRNA crosstalk through a shared pool of microRNAs. stand for transcription rate of each mRNA and correspond to interaction rates between mRNA and microRNA. The other interactions are as in Figure 1A. B,C) Gillespie results for protein mean (B) and noise (C) as a function of transcription rates of the two mRNAs with equal . Parameters same as in Figure 1 with . D,E) Gillespie results for protein mean (D) and noise (E) as a function of transcription rates of the two mRNAs with unequal . Parameters same as in Figure 1 with . Noise surface plots have been smoothed and interpolated for better visibillity. F) LNA results for noise of two non-identical species as a function of normalized transcription rates (with ). All the parameters are chosen to be distinct, i.e. .