ß-catenin stabilization is evident in mammary precancers in HER2/neu transgenic mice.

Mammary gland tissue sections from virgin female MMTV/NDL mice were subjected to ß-catenin IHC as previously described [43] and counterstained with hematoxylin. As a control, serial sections were stained in parallel omitting primary antibody (right-hand panel). Diffuse cytoplasmic ß-catenin was detected in DCIS-like lesions in MMTV/NDL MGs.