Figure_4.tif (465.48 kB)
YM155 increases the degradation of survivin, EGFR, and XIAP in PANC-1 cells.
figure
posted on 2012-06-18, 00:53 authored by Young-Soon Na, Soo-Jin Yang, Seung-Mi Kim, Kyung-Ah Jung, Jai-Hee Moon, Jae-Sik Shin, Dok Hyun Yoon, Yong Sang Hong, Min-Hee Ryu, Jae-Lyun Lee, Jung Shin Lee, Tae Won KimA, After treatment of PANC-1 cells with YM155 for 24 hours, survivin, EGFR, and XIAP mRNA levels were determined using real-time RT-PCR. B, Survivin, EGFR, and XIAP levels in PANC-1 cells after treatment with 50 µg/ml cycloheximide (CHX) in the absence or presence of 100 nM YM155 for the indicated periods were examined by Western blotting. The ratio of survivin, EGFR, or XIAP∶actin expression compared with the control is shown for each lane. *, nonspecific.
