Figure_5.tif (231.76 kB)
Working model for the nematicidal action mechanism by HWY-4213.
figure
posted on 2009-11-11, 01:47 authored by Wan-Suk Oh, Pan-Young Jeong, Hyoe-Jin Joo, Jeong-Eui Lee, Yil-Seong Moon, Hyang-Mi Cheon, Jung-Ho Kim, Yong-Uk Lee, Yhong-Hee Shim, Young-Ki PaikBased on the primary screening results, we hypothesized that HWY-4213 kills the nematode B. xylophilus by inhibiting functions of certain calcium channel proteins as well as the UNC-9 protein in gap junctions, which could result in bursting of calcium ions. The exact mechanism of action involving this calcium channel blocking by HWY-4213 remains to be established.
