Figure_3.tif (1.01 MB)
Workflow and results for Mixed Model analysis of HNE dataset.
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posted on 2008-07-04, 02:08 authored by Lily Wang, Bing Zhang, Russell D. Wolfinger, Xi ChenWhen individual tests were conducted with 6 hr treatment samples and 24 hr samples separately, only 5 and 1 gene-sets were significant at 0.01 FDR level. However, when all samples were used, for testing gene-sets with non-significant Duration×Linear Trend interaction, 40 gene-sets were significant at 0.01 FDR level. This shows pooling data with similar trends from both treatment durations improves the statistical power for identifying biologically meaningful gene sets.