WT and TLR4^−/− mice treated with streptozotocin display a similar profile of hyperglycemia (A) and changes in body weight (B) over a 24 week period including week 6 (WT n = 12; TLR4^−/− n = 9), week 12 (WT n = 10; TLR4^−/− n = 13), week 24 (WT n = 12; TLR4^−/− n = 12) for diabetes groups and non-diabetes controls were 5 mice per group.