Volcano plot illustrating statistical significance of sex-related differences (shown as negative log of the ANOVA P level, so that the most significant differences are on top) in relation to magnitude of mean differences (shown as log of the female/male expression ratio, so that genes expressed at higher levels in women have positive values and those expressed at higher levels in men have negative values).

<p>The lower panel is a magnified version of part of the upper panel, excluding the very large differences for Y-chromosome genes and <i>XIST</i>, which are enclosed in red boxes in the upper panel. The three solid red circles in the lower panel represent the probe sets for the <i>GRB10</i> gene transcript.</p>