Vaccination with Fc-CETP6 attenuates high HFC diet-induced steatosis and NASH.
(A) Representative liver sections stained with H&E (magnification, x200). Liver section stained with H&E from control rabbits showing NASH characteristics, such as ballooning degeneration, infiltrating inflammatory cells and Mallory hyaline were observed in the control (magnification, x200). (B) Expression of RAM-11 (magnification, upper panel x100 and lower panel x400) of the liver from control and Fc-CETP6 rabbits. (C) Expression of NF-kB (magnification, upper panel x100 and lower panel x400) of the liver from control and Fc-CETP6 rabbits. (D) Expression of inflammation related genes in control rabbits (black bars) and Fc-CETP6 rabbits (white bars). The bar graphs represent the average (C: control group n = 7; Fc-CETP6 group n = 8) for each group with standard errors. Values are the mean ± SEM. *p<0.05; ***p<0.001 compared to the control.