Figure_3.tif (46.01 kB)
Two-compartment pharmacokinetic structural model for ivermectin.
figure
posted on 2013-02-21, 10:30 authored by Ahmed El-Tahtawy, Paul Glue, Emma N. Andrews, Jack Mardekian, Guy W. Amsden, Charles A. KnirschThe best fit was obtained by models for two subpopulation (A and B), characterized by different F values, relative to the baseline model that included all subjects. Parameters: central and peripheral compartment volumes, total body clearance (CL), inter-compartmental clearance (Q), rate of absorption, and relative bioavailability (F). Note that albendazole was administered in both baseline and interaction phases.