TrkB expression induces cell spreading dispersal.
A. Morphology of A549 cell colonies and cell dispersal harbouring empty vector (e vector), or expressing wild-type TrkB (wt) or kinase-dead TrkB (kd) plated on noncoated, collagen I or fibronectin-coated dishes. Phase contrast pictures were taken using a 10x objective. Bar, 200 µm B. Bar graphs show quantification of colonies on non-coated dishes. Bars, mean ± SEM (n = 6). C. Bar graphs show quantification of colonies on collagen I-coated dishes. Bars, mean ± SEM (n = 6); (***, p<0.0002).