Transverse sections of statistical parametric maps show the progression of Mn2+ accumulation over time.

Representative transverse sections through the statistical parametric maps show the progression of Mn2+ accumulation over time. Gray background is pre-injection MDT, while the green (1 hr > pre-injection), red (4 hr >1 hr), yellow (8 hr >4 hr) and blue (26 hr >8 hr) overlays indicate areas with increased intensity (P<0.00025) compared to the preceding time point. Videos in Supplemental Data show the complete image data sets for each genotype (Video S3). Slice locations are indicated relative to the brain. Scale bars  = 1 mm.