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Time-response analysis showing percentage changes in 31P-NMR-detected metabolite levels following treatment of KNS42 pediatric glioblastoma cells with PI-103 (5×GI50).

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posted on 2014-08-01, 03:07 authored by Nada M. S. Al-Saffar, Lynley V. Marshall, L. Elizabeth Jackson, Geetha Balarajah, Thomas R. Eykyn, Alice Agliano, Paul A. Clarke, Chris Jones, Paul Workman, Andrew D. J. Pearson, Martin O. Leach

Data are expressed as percentage of treated to control (% T/C) and presented as the mean ± SD, n≥3.

PE in KNS42 cells was not consistently detectable due to the low levels of this metabolite and was not affected by treatment with PI-103.

Glycerophosphoethanolamine (GPE) level was not affected by treatment with PI-103.

Two-tailed unpaired t test was used to compare results in treated cells to controls.

*P<0.05.

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