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Therapy with R-LM249 of systemic metastases induced by the i.v. injection of human breast carcinoma cell line MDA-MB-453.

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posted on 31.01.2013 by Patrizia Nanni, Valentina Gatta, Laura Menotti, Carla De Giovanni, Marianna Ianzano, Arianna Palladini, Valentina Grosso, Massimiliano Dall'Ora, Stefania Croci, Giordano Nicoletti, Lorena Landuzzi, Manuela Iezzi, Gabriella Campadelli-Fiume, Pier-Luigi Lollini

R-LM249 was administered i.p. at 108 pfu dose (4 weekly injections) to groups of 9–10 Rag2−/−;Il2rg−/− mice. (A, C, E) incidence of macroscopic metastases in the indicated organs, as determined at necropsy; (B, D, F) total metastatic burden (mean + SEM) in organs as quantified by human centromeric DNA qPCR. Statistical analysis of differences: panel A, p<0.0001 at Fisher's exact test; panel B, p = 0.0004 at both Student's t and non-parametric Wilcoxon rank sum tests; panel C, p = 0.07 at Fisher's exact test; panel D, p = 0.056 at Student's t test and p = 0.03 at non-parametric Wilcoxon rank sum test.

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