Therapeutic administration of TCDD diminishes SK severity.

C57BL/6 animals infected with 1×104 PFU of HSV were given either TCDD or vehicle IP on day 5 pi. The disease progression was analyzed throughout time. A, The progression of SK lesion severity was significantly reduced in the group of mice treated with TCDD as compared with control mice. Kinetics of SK severity is shown. B, Individual eye SK scores on day 10, 12 and 15 pi. C, The progression of angiogenesis was significantly reduced in the group of mice treated with TCDD as compared with control mice. Kinetics of angiogenesis lesion severity is shown. D, Individual eye angiogenesis scores on day 10, 12 and 15 pi. E, Eyes were processed for cryo-sections on day 15 pi. Hematoxylin and eosin staining was carried out on 6-μm sections and pictures were taken at different microscope augmentations. F, The progression of SK lesion severity was significantly reduced in the group of mice treated with TCDD as compared with control mice. Kinetics of SK severity is shown up to day 28 pi. Data are representative of 3 independent experiments and show mean values ± SEM (n = 14 mice/group). P≤0.001(***), P≤0.01(**), P≤0.05(*).