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The innate immune cytokine response is impaired in the absence of Vα14i NK T cells.

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posted on 2013-02-21, 10:03 authored by Johnna D. Wesley, Marlowe S. Tessmer, Deanna Chaukos, Laurent Brossay

A, Splenic leukocytes were isolated from uninfected or MCMV infected CD1d−/− and CD1d+/− littermates or Jα18−/− and Jα18+/− littermates at 1.5 days post-infection and analyzed for intracellular IFN-γ. The percentage of IFN-γ+ NK cells is shown. The results are representative of 5 independent experiments (*, P<0.05). B, Serum levels of cytokines were measured by ELISA or using the cytometric bead array inflammation kit at 1.5 days post-infection (*, P<0.05). The results are representative of 3 independent experiments. C, Percent survival following high dose MCMV infection.

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