The effects of sphingosine-1-phosphate receptor agonist on the survival of corneal allografts.

A. Opacity, edema and neovascularization of corneal grafts after treatment by S1P1 selective agonist, FTY720, Cyclosporin A and control. B. Mean survival time of rejection free graft after treatment by S1P1 selective agonist, FTY720, Cyclosporine A and control. C. Survival curves of rejection free graft after treatment by S1P1 selective agonist, FTY720, Cyclosporin A and control. Green curve: Cyclosporin A (5 mg/kg/d) treated recipients. Red curve: FTY720 (5 mg/kg/d) treated recipients. Black curve: S1P1 selective agonist (1 mg/kg/d) treated recipients. Twenty mice were used for each group.