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The effects of sphingosine-1-phosphate receptor agonist on the survival of corneal allografts.

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posted on 2014-09-12, 02:49 authored by Min Gao, Yong Liu, Yang Xiao, Gencheng Han, Liang Jia, Liqiang Wang, Tian Lei, Yifei Huang

A. Opacity, edema and neovascularization of corneal grafts after treatment by S1P1 selective agonist, FTY720, Cyclosporin A and control. B. Mean survival time of rejection free graft after treatment by S1P1 selective agonist, FTY720, Cyclosporine A and control. C. Survival curves of rejection free graft after treatment by S1P1 selective agonist, FTY720, Cyclosporin A and control. Green curve: Cyclosporin A (5 mg/kg/d) treated recipients. Red curve: FTY720 (5 mg/kg/d) treated recipients. Black curve: S1P1 selective agonist (1 mg/kg/d) treated recipients. Twenty mice were used for each group.

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