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The effects of MEHP exposure on interaction of RelB/p52 with the CRH/COX-2 gene promoters.

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posted on 2016-01-18, 15:12 authored by Ximi K. Wang, Monica Agarwal, Nataliya Parobchak, Alex Rosen, Anna M. Vetrano, Aarthi Srinivasan, Bingbing Wang, Todd Rosen

Term cytotrophoblast were exposed to MEHP for 24 hrs at concentrations as indicated. ChIP assays were performed to determine occupancy of RelB/p52 at CRH (A) and COX-2 (B), and also occupancy of RelA at the CRH (C) and COX-2 (D) gene promoter. Fold enrichment was derived with normalization to a human DNA a satellite, a non-coding DNA sequence to which no transcriptional factors should bind. Rabbit IgG was used as a non-specific control. The bars indicate the average of fold enrichment with error bars representing the standard deviation from three independent experiments. * p < 0.01.

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