TLR4 deficiency reduced macrophage accumulation in diabetic nephropathy.

Macrophage (CD68+ or F8/40+) accumulation was evident in WT mice with diabetes, but prevented by TLR4 deficiency in both the interstitial (A) and glomerular (B & C) compartments. Data are present as means ± SEM; * p<0.05; *** p<0.001.