TBI accelerated extracellular Aβ deposits in the cortex of AD mice that received TBI.

Statistical analysis revealed a significant increase in extracellular Aβ deposits in the cortex of AD mice that received TBI compared to the NT mice that received TBI and the AD and NT mice that underwent sham surgery (Panel A). Statistical analysis revealed that there was a significant decrease in the number of MAP2 positive cells in the cortex of AD-transgenic and NT mice that underwent TBI surgery compared to the AD and NT mice that received sham surgery (Panel B). Immunofluorescence for the detection of extracellular Aβ deposits and MAP2 (Panel C). Scale bars = 50 µm. The insets correspond to representative high magnifications of MAP2 images. Scale bars = 100 µm. The brain illustration shows the location of the brain slices chosen for histological analysis. ** p < 0.01, *** p < 0.001, **** p < 0.0001.