Superposition of CBD12 from NCX and CALX.

The structures of CBD12-E454K from NCX1 and of CBD12-1.1 and CBD12-1.2 from CALX (PDB codes 3RB5 and 3RB7, respectively) are colored cyan, black and green, respectively. The indicated values represent the hinge angle between CBD1 and 2 as defined by Cα atoms K373, H501 and E647 (NCX CBD12-E454K) and R443, H553 and I692 (CALX CBD12-1.1 and CBD12-1.2).

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