Spontaneous development of marked inflammation in the colon of Shp2 CKO mice.

A: Hematoxylin-eosin staining of paraffin-embedded sections of the cecum, mid-colon, and rectum from control or Shp2 CKO mice at 3 weeks of age. Arrowheads and the asterisk indicate inflammatory infiltrates and a crypt abscess, respectively. B: Hematoxylin-eosin staining of the ileum from control and Shp2 CKO mice at 3 weeks of age. Arrowheads and the arrow indicate inflammatory infiltrates and abnormal villus structure, respectively. All data are representative of three separate experiments. Scale bars, 100 μm.