Several regulators of chromatin remodeling (A) and DNA repair/recombination pathways (B) are required for normal tolerance to caffeine.

We analyzed by sequential spotting as described in Fig. 2D the survival to caffeine or H2O2 exposure at the indicated concentrations of the deletion collection strains 666 (WT), Δpap1, Δrad3, Δssb3, Δrad54, Δrad51, ΔC25A8.01c, Δccr4, Δcaf1 and Δsin3.