Serum IL-10 levels and DENV-specific immune responses.

A: Serum IL-10 levels in healthy dengue seropositive individuals (n = 12), patients with acute dengue infection who did not respond to any of the SS peptides (n = 16) and patients who made responses to DENV-SS peptides (n = 10). The boxes represent the means and the horizontal bars the SEM. B: Ex vivo IFNγ ELISpot responses to DENV-NS3 overlapping peptides and FEC pool of peptides, in patients who did not respond to any of the SS peptides (n = 16) and patients who made responses to DENV-SS (10) peptides and in patients with DF (n = 10) and DHF (n = 16). The boxes represent the means and the horizontal bars the SEM. C: Correlation of ex vivo IFNγ ELISpot responses to DENV-NS3 overlapping peptides and serum IL-10 levels in patients with acute dengue infection (n = 23). P = 0.03 and Spearmans R = −0.45.