Figure_1.tif (4.68 MB)
Selection of healthy NP tissue based on MRI.
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posted on 2013-05-02, 01:51 authored by Munetaka Iwata, Hiroki Ochi, Yoshinori Asou, Hirotaka Haro, Takeshi Aikawa, Yasuji Harada, Yoshinori Nezu, Takuya Yogo, Masahiro Tagawa, Yasushi Haraa) Healthy NP tissues exhibiting high signal intensity on T2-weighted MR imaging were selected and were classified as grade 1 by the Pfirrmann Grading System. b–d) Expression of Col1A1, Col2A1, and ACAN in NP tissues according to Pfirrmann’s grades 1–3 and HNP were analyzed using RT-PCR. Grade 3 NP and HNP tissues exhibited significantly higher expression of Col1A1 than did grade1 NP tissues. For Col2A1 and ACAN, there was a significant difference only in HNP (Fig. 1c, d), *p<0.05. d) Histochemical analysis of sections of NP tissues classified according to Pfirrmann’s grades 1–3 and HNP. Grade3 and HNP cells exhibited typical degenerative histological changes. Scale bar: 20 µm.
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Anatomy and physiologyCell physiologyBiochemistrycytochemistryExtracellular matrixConnective tissuebiotechnologyTissue engineeringhistologyModel organismsAnimal modelsMolecular cell biologyCellular typesConnective tissue cellsgene expressionClinical research designAnimal models of diseaseradiologyDiagnostic radiologyMagnetic resonance imagingsurgeryOrthopedic surgeryAnimal typesSmall animalsnp
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