SMR measurements of dry mass and dry density, samples (S1-S5) with the corresponding modeling based on Advia data (first row, model 1, second row model 2, each column is the same SMR sample).

<p>For model 1, is calculated from the Hb mass model (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003839#pcbi.1003839.e081" target="_blank">Eq. (8)</a>), while for model 2 it is fixed to 11. Young cells (red dots) are evolved using either model 1 or 2 to obtain the older cells (blue dots), and compared to the measured SMR data (purple dots). The green line is an example trajectory of a single RBC. Notice that the simulation results (blue dots) are a small random sample from the entire simulated data, matching in size to the SMR sample size.</p>