RhoA/ROK pathway is (A) activated in early endotoxaemia (blue line) and (B) inhibited in late endotoxaemia (red line).

LPS, lipopolysaccharide; GEF, guanine nucleotide exchange factor; ROK, Rho-kinase; NO, nitric oxide; eNOS, endothelial nitric oxide synthase; iNOS, inducible nitric oxide synthase; GPCR, G protein-coupled receptor; PLC, phospholipase C; DAG, diacylglycerol; PKC, protein kinase C; IP3, inositol 1,4,5-triphosphate; SR, sarcoplasmic reticulum; CaM, Ca2+/calmodulin; MLCK, myosin light-chain kinase; MLCP, myosin light-chain phosphatase; A, adrenaline; NA, noradrenaline.