Figure_7.tif (1.41 MB)
RhoA/ROK pathway is (A) activated in early endotoxaemia (blue line) and (B) inhibited in late endotoxaemia (red line).
figure
posted on 2013-02-19, 15:19 authored by Mei-Hui Liao, Chih-Chin Shih, Cheng-Ming Tsao, Shiu-Jen Chen, Chin-Chen WuLPS, lipopolysaccharide; GEF, guanine nucleotide exchange factor; ROK, Rho-kinase; NO, nitric oxide; eNOS, endothelial nitric oxide synthase; iNOS, inducible nitric oxide synthase; GPCR, G protein-coupled receptor; PLC, phospholipase C; DAG, diacylglycerol; PKC, protein kinase C; IP3, inositol 1,4,5-triphosphate; SR, sarcoplasmic reticulum; CaM, Ca2+/calmodulin; MLCK, myosin light-chain kinase; MLCP, myosin light-chain phosphatase; A, adrenaline; NA, noradrenaline.