Results of LDsplit analysis for association of SNPs flanking DNA3 with hotspot intensity.

For each SNP included in the HAPMAP-CEU phased haplotypes (Table S3), ten estimates of -Log10P values for association with hotspot intensity are plotted (black spots joined by lines). P values of SNPs identified in association studies of childhood ALL are indicated. The boundaries of the DNA3 hotspot used for the analysis are indicated by vertical dashed lines and the corrected P value cut-off is shown by a horizontal dotted line.